> You seem to be speaking about your own link, not the linked article on Hacker News.
Correct. The hacker-news linked article talks about drugs that made mice live longer, my article talks about drugs that made humans live longer with some supporting evidence from mice studies.
> Be especially careful with TRT advice on the internet or from local clinics that push TRT treatments.
Correct. If you read my article, it repeatedly talks about working with a Dr on this. Ideally an endocrinologist (in USA), or potentially a urologist.
Healthy doses of TRT, where studies found benefits are with hypogonadal men whose low T is verified via two separate tests (<200 or <250 total T). The dosages used (~100 mg / week or less) are nowhere near gym bro doses (~200, 300, 400 mg/week etc).
An endo will ask you to make lifestyle changes first, and resort to supplemental testosterone as a last resort.
> it’s on the short list of medicines that can make you permanently dependent by causing testicular atrophy.
I believe you're factually wrong on this. I know a lot of people personally who stopped TRT successfully, some after being a decade on it.
> It’s not appropriate to mix into a list of supplements to take
This is a non-sensical idea, because supplements are much like drugs except they don't go through the FDA approval proceess. They're simply unregulated drugs with potentially significant sides. You shouldn't take a light view of them.
Actually, if I were to choose between a drug and a supplement for the same problem (such as living longer), I think people should prioritize drugs first as they go through rigorous clinical trials, their side effect profile is well known, there's post-approval drug monitoring.
Correct. The hacker-news linked article talks about drugs that made mice live longer, my article talks about drugs that made humans live longer with some supporting evidence from mice studies.
> Be especially careful with TRT advice on the internet or from local clinics that push TRT treatments.
Correct. If you read my article, it repeatedly talks about working with a Dr on this. Ideally an endocrinologist (in USA), or potentially a urologist.
Healthy doses of TRT, where studies found benefits are with hypogonadal men whose low T is verified via two separate tests (<200 or <250 total T). The dosages used (~100 mg / week or less) are nowhere near gym bro doses (~200, 300, 400 mg/week etc).
An endo will ask you to make lifestyle changes first, and resort to supplemental testosterone as a last resort.
> it’s on the short list of medicines that can make you permanently dependent by causing testicular atrophy.
I believe you're factually wrong on this. I know a lot of people personally who stopped TRT successfully, some after being a decade on it.
> It’s not appropriate to mix into a list of supplements to take
This is a non-sensical idea, because supplements are much like drugs except they don't go through the FDA approval proceess. They're simply unregulated drugs with potentially significant sides. You shouldn't take a light view of them.
Actually, if I were to choose between a drug and a supplement for the same problem (such as living longer), I think people should prioritize drugs first as they go through rigorous clinical trials, their side effect profile is well known, there's post-approval drug monitoring.