Scaling mouse doses to human by body weight is a common rookie mistake.
A better estimate for dose scaling uses body surface area. Even with that, inter-species differences don’t allow prevent extrapolation.
Scaling by body weight leads to the common mistake of dismissing mouse studies because the casual observer does the match (by weight) and thinks the dose used was excessive.
It’s such a basic topic in medicine and scientific research that I don’t trust anyone who scales by body weight.
A better estimate for dose scaling uses body surface area. Even with that, inter-species differences don’t allow prevent extrapolation.
Scaling by body weight leads to the common mistake of dismissing mouse studies because the casual observer does the match (by weight) and thinks the dose used was excessive.
It’s such a basic topic in medicine and scientific research that I don’t trust anyone who scales by body weight.