Rapamycin and related rapalogs will be far better than metformin at inhibiting mTORC1, and at a low and intermittent dose of 4-6 mg ONCE per week are quite safe. Best paper I know of now is Kaeberlein et al 2023:
What about stuff like Berberine? Is that all smoke and mirror? It's always hard to tell if the research around "traditional" compounds is actually legit or just other countries engaging in what is effectively marketing.
