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-itis refers to a specific physiological phenomenon: Inflammation (https://en.wikipedia.org/wiki/Inflammation)

swelling can happen without inflammaion, and mild inflammation may occur without noticable swelling.

-osis is a generic suffix for a process or condition: metamorphosis, scoliosis, hypnosis.



> and mild inflammation may occur without noticable swelling.

Calor, dolor, rubor, tumor


They are not definition. Maybe they were, when we didn't know about cytokines and immune cells.




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