Lisp is more of a meta-language than a mere language. Since it's homoiconic, you eventually end up developing a domain-specific language that works great for your subject area. It also may make it a bit harder to onboard new team members, because the level of abstraction which you can reach can be relly high, all while keeping performance reasonable.

Technically, you could run e.g. a Python program under pdb, break on certain exceptions, and fix things inside a living system. It's just not a customary way to do that.