I have used mostly default keybindings in Emacs for over a decade and what hurts my wrists the most is web applications that force me to use the mouse.
I use Kinesis Advantage keyboards where one of the keys in each thumb cluster is control, and my capslock is Super. The latter is because Emacs is my window manager and Super is the modifier key for WM commands.
I think Emacs did permanent damage to my hands before I got a special keyboard. "Works for me, wontfix" isn't a good position to take on that kind of issue.
It is perfect on Sun keyboards up to Type 4 and IBM keyboards up to Model F. Starting with Type 5, Sun adopted the giant caps lock key next to the pinky layout that IBM Model M keyboards used, but many Emacs users remap control back to where it should be anyway.
It's actually more appropriate for a space cadet design:
Hyper | Super | Meta | Control | Spacebar | Control | Meta | Super | Hyper
which was available when emacs keybindings were solidifying (they originated essentially as "hey, what do you people have configured?" poll around the lab/mailing list)
Note that the modifier keys are mirrored, and Emacs' most used key (control) is closest to spacebar. Essentially, you weren't supposed to use control with your pinky while stretching your hand to hit another key - but to use opposite hand for modifier. Suddenly RSI is much less of an issue. Unfortunately not only order of keys on a modern keyboard is different (and often you lose some keys) a full 104 key has
Ctrl | Super | Alt/Meta | Spacebar | AltGr/Meta | Super | Hyper | Control)
which is noticeably non-mirrored, depending on one's language might also lose right Meta key, and for some reason you now commonly get PrtScr/SysRq in place of Hyper on laptop keyboards.
