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This is the first drug that actually works in the initial stages, isn't it?


No, it isn’t. There’s at least one steroid (dexamethasone) and There are at least three other off label treatments which have shown some efficiency at early stages (IVermectin, hydrochloroquine, and another one whose name escapes me).

Of these, ivermectin’s safety profile is “incredibly safe”, hcq “mostly safe with some caveats”; don’t remember about cholcocine or whatever it is called.

I am perplexed at the complete and utter avoidance from western countries (including US, Britain and Israel) of these.

Yes, vaccines are a better solution long term, and it is good to give them high priority. But there isn’t really a competition for resources here. I just can’t understand it.


>I am perplexed at the complete and utter avoidance from western countries (including US, Britain and Israel) of these.

Dexamethasone's effects were discovered by a study in the UK, and: "Changes in the NHS covid-19 treatment protocol were soon announced based on these results". My wife confirms this, she's a nurse.

https://www.bmj.com/content/370/bmj.m2648

Hydrochloroquine is not effective as a Covid-19 treatment: "However, available evidence does not support the use of this medication in the prevention or treatment of COVID-19."

https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9...

As for ivermectin: "Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients."

Although they do recommend further studies. It seems it could be useful, but there are alternative treatments available now that are more effective.

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5...


> I am perplexed at the complete and utter avoidance from western countries (including US, Britain and Israel) of these.

Dexamethasone is a standard treatment in the UK in line with WHO guidance[1]. Its use was first recommended in June 2020, before the final analysis of the RECOVERY study results was even published[2]. I was treated with it in October 2016.

Hydroxychloroquine was trialed, and found not to be effective in hospitalised patients[3].

[1] https://www.england.nhs.uk/wp-content/uploads/2020/11/C0870_...

[2] https://www.gpni.co.uk/wp-content/uploads/2020/06/DEXAMETHAS...

[3] "On 5 June 2020, the trial determined that there was no clinical benefit from use of hydroxychloroquine in people hospitalized with COVID-19." https://en.wikipedia.org/wiki/RECOVERY_Trial#Hydroxychloroqu...


Can you post some references to studies showing these drugs' efficacy? (apart from dexamentazone which is of course known to have been shown to be effective already).


For HCQ, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534595/

There's another site I cannot remember the domain of now, that aggregates as many studies as it can find. It claims something like 2/3 of studies show positive effects.

Edit: Found it, and it includes links at the top for similar sites on Ivermectin, Vitamin D, Zinc, etc - https://c19study.com/


https://c19ivermectin.com/

Reddit.com/r/ivermectine



The US bought millions of doses of hydrochloroquine. If it worked, we'd be using it, not wondering what to do with it.

Zinc!, Vitamin C!, the other thing!


HCQ might still be useful if administered with zinc, that's been the working theory since the beginning but has been lost in the madness. There's at least one study to that effect, which incidentally goes to great lengths to hide the fact that they are using HCQ to boost intracellular zinc concentration. Zinc has been known to slow viral replication, so that makes people deficient in it more vulnerable.


I think I recall reading that study and seeing it compared people who took zinc with HCQ with people in the hospital and concluded that people in the hospital died more often than mostly healthy people. Hardly what I would call useful information.


Zinc!




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