I recently saw this about AlphaFold: https://elanapearl.github.io/blog/2024/the-illustrated-alpha.... I don't think it's going to answer all your question but it might still help!

I have been enjoying https://oku.club/ recently in case anyone is searching for a nicely functioning alternative.

I believe the parent refers to this [1,2,3] study. Indeed, this was about targeting many (11,923) genes with Perturb-seq (CRISPR screen with single-cell RNA-sequencing readout). There are two human cell lines used in the study (K562 and RPE1). For functional annotation, authors focused on 1,973 targeted genes that had strong transcriptional phenotype after the perturbation. As there's some correlation structure, that's what they studied, annotating clusters of individual perturbations using public databases (like STRING [4]) and literature. Seems like a lot of great work has been done here though stating that we now know all the functions of all the genes might be a bit of a stretch indeed.

[1]: https://news.mit.edu/2022/crispr-based-map-ties-every-human-... [2]: https://www.cell.com/cell/fulltext/S0092-8674(22)00597-9 [3]: https://gwps.wi.mit.edu/ [4]: https://string-db.org/

Seems to be an immortalized (telomerase*-transformed) cell line from a female fetus with near-complete homozygosity (https://sites.google.com/ucsc.edu/t2tworkinggroup/chm13-cell...).

* Telomerase is a reverse transcriptase that allows to achieve replicative immortality (https://academic.oup.com/hmg/article/9/3/403/715108).

Sounds similar to the consequences of reading Don Norman's «The Design of Everyday Things»...

That book was part of my classes

Maybe something like that is relevant: https://science.sciencemag.org/content/371/6525/145. There's also a bit more context here: https://www.nature.com/articles/s41587-021-00880-0.

To add to the collection of websites recreating acoustic environments, there's https://imisstheoffice.eu for office sounds.

Rectangle (https://rectangleapp.com/) is Spectacle's successor, works great, and its source is available as well (https://github.com/rxhanson/Rectangle).

I think the quote is from the keynote itself. Here's the timestamp: https://youtu.be/GEZhD3J89ZE?t=4250.

For some reason the CC is out of sync, it's couple minutes earlier https://youtu.be/GEZhD3J89ZE?t=4122