OP mentions "six minutes" as a DB metric. But the thing is that DB doesn't care about trains being late. It's absolutely normal to have an hour delay in Germany. You can be considered lucky if it's under an hour. What will usually happen is that you spend half a day in some village waiting for your connection and travel the rest of the way standing in the doorway with your bags.
I've been on UK trains that were an hour late, others that changed platform at least three times, headed to the wrong destination etc.
Many are cancelled without a decent reason being given. I rarely take British trains now they are so expensive and unreliable. Only long distance maybe because buses are unpleasant.
There're certain kinds of rewards to encourage traveling by rail in Europe. For example, a training course I attended refunded part of your travel expenses if you took a long-distance train. And there're people who believe in not flying for the sake of the planet.
But at this point, I'm convinced you should avoid any train in and around Germany. This includes Denmark as well. Just take a plane, but don't have a layover in Germany. The same could probably be said about France. My first train from Paris to Nancy stopped for about 2hrs in the middle of nowhere. As the machinist said: "The train is tired."
Other countries like Italy or Spain seem to actually have well-functioning rail though.
I regularly travel on DSB (2.5hr journeys, 4 times a month minimum), and only very rarely encounter issues. Staff have always been easy to deal with and on the rare occasion I've had to be refunded (the carriage with my reserved seat didn't show up) I've received it within days.
Nope, leave Italy off the well-functioning rail. I am a commuter, i use the train here since 2009 and it's terrible. We're going through the same experiences described in the post, but often even much worse. On December 1st, my train took 6 hours to travel 100km instead of 1 hour so we too felt like the post author.
I have a relative with the same disease. They went to a an eye doctor because of visual artifacts. Turns out the tumor was so big it caused retinal detachment. Basically, most people get diagnosed at a very late stage because it's mostly asymptomatic.
First issue is that tumors don't necessarily have to be highly immunogenic, e.g. there're tumors that don't present many neoantigens on the surface. This means immune cells can't easily recognize them. Second issue is that tumor microenvironment evolves to be immunosuppressive. There're many different signals that regulate immune cells activation and simply having antigen-specific cells isn't enough. But as someone said in a sister thread, what you're describing is a basis for multiple clinical trials that combine antigen release with immune activation.
Yes, we were doing a clinical trial where the primary tumor was irradiated which causes antigen release. The patients were given immune checkpoint inhibitors at the same time to activate immune cells. It's promising but tricky.
> Releasing a bunch of loose cancer into the body is a clear causal mechanism
I'm not in cancer field, but I'm not sure it is. AFAIK the cells that metastasize need to undergo EMT. Simply releasing them from the tumor doesn't mean the cells can attach and survive in the distal site.
I don't download any apps anymore, so not very informed on the state of alternative app stores in EU. I decided to Google where I can find those. One of the first links is leading to MacPaw's website. It's a company with questionable ethics and business practices that tries to sell you "antivirus" and "decluttering" app. So I'll pass.
But are there any real 3rd-party AppStores for iOS now? Something that's used by more than just a couple of people? Or is EU just trying to milk rich USA tech giants (I think I know the answer).
However, according to Apple's docs, they only allow alternative app stores in the EU and Japan, so you have to be using an iOS account with the region set to one of those two places and be physically located there in order to install the app store. Not something that's easy to experiment with for people in the USA to see how the other half lives.
> Or is EU just trying to milk rich USA tech giants (I think I know the answer).
I don't really see an angle for the EU to do much milking here. Actually I think the AltStore founders are Americans? So they seem to be reaping the benefits of EU and Japanese legislation, remotely.
> fixing the enzyme that fixes the wrong copy paste mechanism
The DNA fidelity issues contribute to only some cancers. Many are caused by mutations due to environmental damage and some are caused by viruses. The point is, there's a huge variety of reasons for developing cancer. So you cover more cases by developing treatments that are more "universal".
Turns out that an online certificate isn't worth anything when layoffs happen and the market is oversaturated with people who have real degrees. MOOCs have their place, but it's a very narrow set of disciplines.
It's probably not a uni specific issue. I went to a top EU uni, and there absolutely were courses that could've just been an ~~email~~ video. Admitedly not everything was bad, but the quality of education isn't as high as it should be.
More students _per course_ than a MOOC cohort? -- doubt.
If you add up all courses of a while discipline, edu portals still serve way more students.
In our department, about 20% reach a master. Sure that's more well rounded than a random bunch of courses, but it should be possible to even surpass the rigid choices of a lot of universities.
I have no numbers for MOOCs at hand. If I had to guess: more like a gym: a lot of members, an order of magnitude less finishers?
I personally prefer the interaction on campus.
But I dislike the outdated content of a lot of professors -- I'm not arguing about basics that are still relevant, I mean their /SoTA/ from 5-15y ago.
Well, I work at a university too. At least in biomedicine, every MOOC is extremely shallow. The most advanced MOOC is an introductory-level when compared to the university courses.
I wouldn't be so tough on the online certificates. The key value I get out of Coursera is an unbeatable "time to knowledge" and some proof it was me who attended the course through the id verification.
Compare that to traditional in-person education, where you are bound to fixed course dates, long approval timelines etc. Until you get feedback from HR that you are eligible for a course/training, i've probably already completed it via my Coursera complete subscription.
I'm not sure offline certificates mean a whole lot when layoffs matter either.
But MOOCs and other purely online options just didn't result in any meaningful certification especially outside of a connection to established universities. And, given that, people/companies weren't interested in paying significant bucks for them.
It was probably a useful experiment. Just not a very successful one. And once the experiment faltered, schools/professors became less interested in putting money and energy into it.
All the evidence is that most of the students/potential students who weren't already motivated to pursuing independent learning didn't really connect to all this online material.
It's not a question whether they are or not worth something. It's just that it's a much more meaningful differentiator when there's an overabundance of talent. CVs are going to be filtered based on something. And people with no degree are going to have a much more difficult time getting through the automated screening. That will come as a surprise to people who were promised they'll get a job by paying $1000 for a "nano-degree".
