It looks like they're pivoting into corporate finance tracking which seems like a good move but still a bit jarring as I was curious to give this a go!
Existing customers - what comms have you received?
I don't really want to self-host this even though I might. Before I commit, what are some alternatives? The UI seemed very compelling
Selegiline is also known as Emsam, the patches reportedly Sam Bankman-Fried was on, alongside ADHD meds. I recall reading how this may have been a large driver of his compulsive risk it all decision making that eventually brought it all down.
Delivery through transdermal patch (Emsam) is different than other presentations of Selegiline, and we don't know the doses he was on. I've heard a low dose of Emsam (6mg) gives a better, more stable dopamine baseline, without getting into MAO-A inhibition that happens at upper doses.
> I've heard a low dose of Emsam (6mg) gives a better, more stable dopamine baseline, without getting into MAO-A inhibition that happens at upper doses.
This is the broscience theory that you find on Internet forums, but it didn’t play out positively in the actual clinical trials. Getting into full MAOI inhibition was necessary for positive effects.
The “more dopamine” theory appeals to people who treat the brain as a simple machine where you’re adjusting levels of different chemicals, but doesn’t really work out in practice. Dopamine is the neurotransmitter du jour in these circles, but mood and mental health are more than one chemical.
Thanks for the info, I was missing an update on this space. If there's no solid, reproducible evidence of cognitive or energy benefits at this level -and full MAO‑A engagement seems necessary for those effects, then that doesn't look good.
About your second paragraph, I agree and I wasn't validating the bro part, just that I read about Emsam once. I guess it's mostly influenced by the popularity of performance enhancers in general, be it wakefulness enhancers, stimulants, etc. People are always trying to find "the edge", without the tradeoff, basically chasing a mirage.
Maybe a neglected topic in this theme has been the acetylcholine pathway. Cobenfy, for example, has been approved for treating negative symptoms of schizophrenia and it's not a classical drug in that space.
Try telling all this to someone who is effectively emotionally/physically disabled because their mind and body either enter a rollercoaster or just shutdown in response to anything vaguely reminiscent of something they experienced.
I think these treatments are better understood as methods to encourage one's mind and body to reprocess some experience so that it is "merely" a terrible thing that happened so they can live a stabler, more balanced, more normal life.
The tribe that you speak of is much much bigger than those who have an official diagnosis of PTSD via psychology. For example, addicts all have PTSD that is commonly related to past childhood/family abuse dynamics. They take drugs over it. So, as a matter of fact, that is exactly what is told to them. You can in fact hold your pain, and I believe it is righteous to do so.
It kind of reminds me of Eternal Sunshine of Spotless Mind. You cannot just erase something. Drugs effectively erase the bad feelings, but they don't last. Okay, so such a treatment being discussed is, I suppose, an everlasting solution. Why would I be against this? Because you cease being you in your entirety (which includes your trauma).
It's not an easy sell by any measure, especially for those who just go "well fuck that, I can erase this with some cocaine right now". Erasing it is a solution, for sure, but it's not a free solution. Something is lost in the process (you). Understanding that, stay with me here, that it's beautiful is part of it, that you have a beautiful part of you forever. It's completely didactic, you have to teach the person that they went through something and are PRETTIER in their surviving of it. Then it stops being traumatic.
If we zap them, we take away the pretty. If I zap you, and then say lets talk about it, and you say "well I don't feel any which way about it anymore", then it's lost. It's gone. So something is lost in the process. So yeah, this is exactly what is told to the most beaten down people in life.
There are "better" databases but they're better given some particular definition that may not be relevant to your needs. If SQL/the relational model and ACID semantics is what you need then postgres is simply the best in class. The fact it dates back to the 80s is probably an advantage (requirement?) when it comes to solving a problem really well
The Wikipedia page on this is sufficient. If F:X -> Y is a function between normed linear spaces then DF:X -> L(X,Y), where L(X,Y) is the vector space of linear operators from X to Y, satisfies F(x + h) = F(x) + DF(x)h + o(h). A function is differentiable if it can be locally approximated by a linear operator.
Some confusion arises from the difference between f:R -> R and f':R -> R. It's Fréchet derivative is Df:R -> L(R,R) where Df(x)h = f'(x)h. Row vectors and column vectors a just a clumsy way of thinking about this.
My best guess is a lack of willing participants combined with pressure from up top to move money to keep the operation going/meet targets.
We also don't know how much of that 500k is profit - maybe the margins in organised crime aren't what they used to be. Each $3,750 saved is money they can put straight into their pocket as their boss might never find out how many mules they ended up using.
I think it’s pretty simple. To many people, $3,750 is a huge amount of money. It’s easily several months salary.
I think a lot of people would be relatively unaware of how illegal a given thing is and would instead see the amount of money being offered as representative of the risk. Too much and they would get suspicious.
Even at effective minimum wage of 11.80 an hour[1], that’s only 2 months of salary. That’s not life altering in any way and wouldn’t be worth prison time to people in general. People have to have been tricked about the risks or were coerced.
People on minimum wage don’t get a chance to build savings are probably living month to month. Though it’s not an earth shattering of money it is meaningful to a lot of people.
I remember some very sad news about a drug smuggler, a poor woman from the Philippines, condemned to an insanely harsh sentence in Singapore (perhaps even death penalty?). At least, the UK justice system should be less cruel.
Writing blog posts is the lowest barrier of entry there is to contributing to the sum total of knowledge for some particular keywords, problem space. Sometimes even, years of blogging gets edited and expanded upon into an entire book but I suppose no one cares about those either.
Yes, the concept of rooms is analogous to rooms in a chat service. One difference from IRC as a protocol (besides being over websocket) is that each connection corresponds to exactly one room (since different rooms may be on different servers.)
It looks like they're pivoting into corporate finance tracking which seems like a good move but still a bit jarring as I was curious to give this a go!
Existing customers - what comms have you received?
I don't really want to self-host this even though I might. Before I commit, what are some alternatives? The UI seemed very compelling